Žinios

Kaip rapamicinas gavo savo pavadinimą?

Feb 23, 2022 Palik žinutę

Rapamicino milteliaigali būti naudojamas medicinos srityje. Rapamicinas yra makrolidinės struktūros antibakterinis vaistas, kuris gali tam tikru mastu slopinti imuninę funkciją. Šiuo metu rapamicinas yra kliniškai naudojamas prieš{0}}atmetimą po organų transplantacijos ir pagalbiniam kai kurių vėžio formų gydymui.

If you search the web page now, you will find that its title often contains words such as "magic medicine". It would be too rough to know rapamycin from the identity of antibacterial drugs and immunosuppressants. The word "magic medicine" refers to the future rapamycin, or a drug with similar structure and function, which is expected to become an anti-aging drug that prolongs human lifespan.

Rapamycin was discovered on Easter Island (Rapa Nui) in Chile. There are many historic giant stone statues on this island, called "Moai". These stone statues have strange expressions and all of their faces are in the same direction. The local people do not know that these stone statues are used for what to do.

In 1964, a Canadian scientific expedition team came to Easter Island, and this team has not made new discoveries for a long time. At that time, "scientific research" was popular, running around the world, collecting all kinds of soil that may have new discoveries, separating microorganisms and microbial secondary metabolites from the collected soil to find new antibiotics. The group of researchers found that the islanders are barefoot and have a lot of horses. In that era, raising horses would increase the probability of tetanus infection. Before fighting, ancient archers inserted arrows into horse dung to enhance their "weapon power", and the enemy of the battlefield would be infected with tetanus and die; while there was no infection of the residents of Easter Island, and the scientific researchers guessed that there may be antibiotics on the island.

Researcher Georges L. Nógrad is the person responsible for collecting soil samples in the team. When they passed the Moai stone statue, Nógrad found that there was a piece of land under the stone statue that was in shadow all year round. He collected this kind of soil sample. More than 60 samples were taken from the island. Nógrad returned to Canada and observed tetanus spores (the dormant body of tetanus bacterium) in the soil himself, and found that only one soil sample had tetanus spores, and the other 60-odd soil samples did not.

Nógrad hurriedly handed the sample to Ayerst, a Canadian pharmaceutical company, where a doctoral researcher named Surendra N Sehgal found that the soil on Easter Island (Rapa Nui) did indeed contain unprecedented levels of antifungal antibiotics, hence the name Rapamycin.

Ir taip rapamicinas gavo savo pavadinimą. Jei norite gauti aukštos kokybės{0}}rapamicino miltelių, mūsų įmonė yra geras pasirinkimas bendradarbiauti. Jei turite klausimų, nedvejodami susisiekite su mumis, mes dirbame bet kuriuo metu.

Siųsti užklausą